Peritoneal mesothelioma
Health medical terminology medical terminology gastroenterology disease lifePeritoneal mesothelioma (peritonealmesothelioma) primary in the tumor epithelium and peritoneal mesothelial organizations. Pathology can be categorized as adenomatous mesothelioma (adenomatoidmesothelioma), cystic mesothelioma (cysticmesothelioma) and malignant mesothelioma (peritonealmalignantmesothelioma, PMM).
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table of Contents
1 Pathogenesis2 Diagnosis
3 etiological diagnosis
4 treatment
5 drugs
6 Disease Prevention
7 related terms
8 Reference Links
Peritoneal mesothelioma
Peritoneal mesothelioma
Peritoneal mesothelioma (peritonealmesothelioma) primary in the retroperitoneal tumor epithelial and mesothelial tissues. Pathology can be categorized as adenomatous mesothelioma (adenomatoidmesothelioma), cystic mesothelioma (cysticmesothelioma) and malignant mesothelioma (peritonealmalignantmesothelioma, PMM). The first two belong to a benign tumor. Has no clinical characteristic, common signs and symptoms include: abdominal pain , ascites, abdominal distention and abdominal mass, and so on. Peritoneal mesothelioma accounts for approximately between mesothelioma 20% of cases, can occur in 2-92 years, mean age was 54 years, of which about 63% of cases between 45-64 years of age, children are rarely sick.
Peritoneal mesothelioma - Pathogenesis
Factor in the long-term diet, lifestyle, etc., causing the acidic, the overall body function decline, causing the body tube local lesions, when a large number of peritoneal portion cumulative deposition of acidic substances in the future, causing the parts of the lesion.
Body tissue fluid acidification, brain cells in the acidic body fluids, thus the formation of peritoneal mesothelial cells dissolved oxygen decreased, resulting in decreased activity of the cells slows down metabolism and circulation, decreased to 65% of normal, normal cells can not survive, but there are not hesitate to take the initiative to change the chromosome mutation cells, cell phenotypic changes, tumor characters to express, the rapid expansion of these cells to form a true tumor entity.
In addition, due to the acidic body other cancerous tissues, and because part of the body function decline, peritoneal mesothelial tissue fluid acidification, cancer stepped in, resulting in a peritoneal mesothelioma.
Peritoneal Mesothelioma - Diagnosis
1. Question history of unexplained abdominal pain, bloating and digestive disorders, abdominal pain can be expressed as diversification, but the pain is intractable is their common characteristics. belly
Peritoneal mesothelioma
Peritoneal mesotheliomaAtlas
A high incidence of water, more than 90% in a short or long period of abdominal pain, the sudden appearance of ascites, ascites, but also may appear alone at an early stage. Ascites quantity and stubborn. Rarely systemic change in the longer term, to maintain appetite, weight loss was not obvious, no fever, sometimes spontaneous hypoglycemia. It may be associated with chest pain, breathing difficulties, coughing and other symptoms of pleural mesothelioma. 2. Physical examination revealed abdominal distension, or were frog belly, shifting dullness positive; abdominal palpation palpable size ranging from single or multiple swelling blocks, general tenderness not obvious. As with pleural mesothelioma, pleural effusion can be found positive signs. 3. Laboratory examination B ultrasound and CT examination can be found flaky image and ascites tumor. Ascites exudate, may also be bloody. Hyaluronic acid, such as ascites increased to 120ug / ml, helpful for diagnosis. Ascites mesothelioma cells to find new biological diagnostic value, but also on the middle ascites mesothelial cells chromosome analysis, diagnosis. Laparoscopy visible peritoneal surface covered with plaques and nodules, biopsy can confirm the diagnosis. It should be noted with tuberculous peritonitis, peritoneal metastases phase identification.
Peritoneal mesothelioma - etiologic diagnosis
Peritoneal mesothelioma is the primary peritoneal mesothelial cells in the tumor. Has no clinical characteristic, common signs and symptoms include: abdominal pain, ascites, abdominal distension
Peritoneal mesothelioma
Peritoneal mesotheliomaAtlas
Abdominal mass and so on.
Peritoneal mesothelioma is the primary peritoneal mesothelial cells in the tumor. Has no clinical characteristic, common signs and symptoms include: abdominal pain, ascites , abdominal distention and abdominal mass, and so on. Peritoneal mesothelioma accounts for about 20% of all mesothelioma cases, can occur in 2-92 years, mean age was 54 years, of which about 63% of cases between 45-64 years of age, children are rarely sick.
In daily life, regular physical examination, always pay attention to whether your body a sign of peritoneal mesothelioma, we should find out if there is some response in the end is what causes discomfort. To diagnosed with brain cancer is not a need to go to the hospital to do a specific check to see if your blood test indicators, CEA, CA125, do NMR diagnosed.
If the diagnosis of peritoneal mesothelioma, first panic, we must make a judgment should be treated according to the specific circumstances, and conduct the consultation. General cancer surgery is not easy, especially in large tumors have been oppressed nerve or near large blood vessels of the case. We recommend conservative treatment, to diet.
Peritoneal Mesothelioma - treatment
PMM is a rare peritoneal malignant, always considered the prognosis is poor, there is no standardized treatment program, but this situation is expected to change. With surgery,
Peritoneal mesothelioma
Peritoneal mesotheliomaAtlas
Chemotherapy , radiotherapy combination therapy, immunotherapy supplemented began to take shape.
He complained of chronic abdominal pain, and bloating in elderly patients, particularly those with ascites and (or) abdominal mass, by ultrasound or CT examination confirmed the intra-abdominal masses or peritoneal nodules; ascites was exudative, ascites hyaluronic acid increased significantly; serum CA125 rises, should be highly suspected PMM. These patients should be under ultrasound or CT-guided biopsy, laparoscopy, or laparotomy; at the same time, the estimated range of tumor proliferation, in the visceral and parietal peritoneum multiple biopsies to obtain adequate tissue for pathological examination and immunohistochemical or chemical examination. Most patients diagnosed PMM, has been difficult to complete surgical resection of the tumor. If there is no obstruction performance, should be given within two to three courses of chemotherapy-induced abdominal cavity in order to minimize the tumor in the bowel surface planting, to create conditions for surgery and help clinicians master data tumor response to chemotherapy. After induction chemotherapy for 2 months, the implementation of cytoreductive surgery, removal of peritoneal lesions, so as to remove all tumor tissue. Intraoperative or early postoperative period should be given in the adjuvant intraperitoneal chemotherapy, and radiotherapy and BRM with adjuvant therapy. Postoperative tumor recurrence, such as conditions permit should be considered before surgery.
Peritoneal Mesothelioma - treatment
PMM moderately sensitive to chemotherapy, preoperative chemotherapy, surgery and postoperative adjuvant chemotherapy can significantly reduce tumor recurrence and improve the 3-year survival rate.
Peritoneal mesothelioma
Peritoneal mesotheliomaAtlas
PMM positive therapeutic effects of chemical drugs doxorubicin , cisplatin , carboplatin, bleomycin and domestic anti-cancer drugs Eiemene like. Vincristine, fluorouracil, cyclophosphamide, mitomycin also worth a try. Doxorubicin (Adriamycin, ADM) for each adult 30 ~ 60mg / m2, every 3 weeks, intravenous or intraperitoneal injection, not to exceed a total dose of 550mg / m2. Adverse reactions to cardiac toxicity, and there is accumulation, and the total dose; followed by bone marrow suppression, gastrointestinal reactions and alopecia.
Cisplatin (Cisplatin, DDP, cisplatin) for each adult 80 ~ 120mg / m2, 1 every 3 weeks; or 20mg / m2, once every five days, every 3 weeks for a course of intravenous injection. Adverse reactions are nephrotoxicity, ototoxicity, neurotoxicity, gastrointestinal reactions and suppressed bone marrow and the like. Add to reduce its accumulated in the renal tubules mannitol.
Carboplatin (Carboplatin, CBP) for each adult 300 ~ 400mg / m2, 5% glucose solution or saline, diluting the concentration of 0.5mg / ml solution intravenously repeated every 3 to 4 weeks or 100mg / d , 5% glucose solution 500ml intravenous infusion for 5 days; 3 to 4 times a week to repeat. Can also be used for each 300 ~ 500mg intraperitoneal injection once a week.
Bleomycin (Bleomycin, BLM) adult 15 ~ 30mg, dissolved in an appropriate amount of saline or 5% dextrose solution deep intramuscular, or intravenous injection, 2 times a week; the case may be, to a time / d or several times a week. After intraperitoneal injection of slow further 60mg dissolved. Stey with internal BLM intraperitoneal injection, for one case of PMM patients, the results of ascites disappeared, the withdrawal did not happen again, survived for more than three years. However, large doses of BLM intraperitoneal injection can cause pneumonia-like symptoms, and even pulmonary fibrosis; In addition, fever, gastrointestinal reactions more common. Patients allergic individual.
Taxol (Paclitaxel) This product is extracted from the yew bark anticancer drug induce and promote tubulin polymerization and depolymerization and prevent stable microtubules, inhibiting the cell mitosis and proliferation. Taxol can inhibit mitotic microtubule network required for regeneration, impede mitotic spindle formation leads to chromosome breakage, inhibiting the replication of tumor cells. Dose of 135 ~ 175mg / m2, diluted in normal saline or 5% dextrose solution intravenously. Repeated every 3 weeks. 12 hours before treatment should be given dexamethasone 20mg, 30 ~ 60 minutes ago should intravenous diphenhydramine 50mg and cimetidine 300mg or ranitidine 200mg, to prevent allergic reactions. Combined with about 66.7% of the patients effectively with cisplatin and ability by its toxicity. Adverse reactions are bone marrow suppression, allergic reactions, arthralgia , myalgia , gastrointestinal reactions, peripheral neuropathy, syncope, ataxia, and injection site pain and so on.
Peritoneal mesothelioma
Peritoneal mesotheliomaAtlas
Eiemene (Elemene) Chinese medicine extracted from Curcuma to anti-cancer substances; thoracic, intraperitoneal infusion treatment of malignant ascites and pleural fluid has a good effect. Try pumping in ascites, according to 200 ~ 400mg / m2 intraperitoneal injection dosage, 1 to 2 times per week. The occurrence of adverse reactions was 20% to 70%, mainly fever, chills and pain; inject a small amount as a pre- anesthetic and hormones , is able to prevent it; other allergic reactions, gastrointestinal reactions.
Cyclophosphamide (CTX) for each adult 600 ~ 1200mg, 1 or 2 times per week, intravenous injection. Bone marrow suppression, gastrointestinal reactions and hemorrhagic cystitis more common adverse reactions after treatment.
Vincristine (VCR) for each adult 2.5 ~ 8mg / m2, 1 times per week, intravenous injection, a total of 60 ~ 80mg, main side effects of bone marrow suppression.
Methotrexate (MTX) for each adult 15 ~ 50mg, 1 to 2 times a week, muscle or intravenous injection. Side effects are bone marrow suppression, gastrointestinal reactions, stomatitis, liver and kidney dysfunction, long-term medication can cause pulmonary fibrosis.
Peritoneal Mesothelioma - Disease Prevention
Peritoneal mesothelioma originated in the epithelium and peritoneal mesothelial organizations, asbestos dust pathogenic substances, some viruses may also cause mesothelioma. Peritoneal
Peritoneal mesothelioma
Peritoneal mesotheliomaAtlas
Mesothelioma pathology can be divided into: adenomatoid tumor, cystic mesothelioma, malignant mesothelioma and three. Peritoneal mesothelioma clinical manifestations are not specific, relevant test positive rate is not high, specificity is not strong, the clinical diagnosis very difficult. With laparoscopic examination, ultrasound and CT-guided conduct and pathology, improve immunohistochemistry and electron microscopic diagnosis of biopsy techniques, a growing number of cases before surgery during his lifetime or get a clear pathological diagnosis. Peritoneal mesothelioma should primarily with tuberculous peritonitis, intra-abdominal metastases, other primary peritoneal omentum differentiated tumors. To date, peritoneal mesothelioma is still a lack of effects of treatment, including the vast majority of scholars advocate surgery, postoperative radiotherapy and chemotherapy comprehensive treatment measures.
research shows:
① cancer can not be formed in the alkaline body;
② cancer only in an acidic body is formed;
③ If you have cancer, indicating the body is acidic;
④ cancer only in one acidic body extension;
⑤ If your body becomes weak alkaline , cancer can not be extended;
⑥ If you can balance your body PH value, so that your body into alkaline, no matter what you have to change and cancer has been cured;
⑦ No matter how bad your situation, even if only six months to live, if you can change your body PH value to weak alkaline, your cancer will not be extended, it will be good;
⑧ not worry about your family, your mom, dad or anyone who has cancer , as long as your body is alkaline, you will not have to, if you already have, it will change;
⑨ are acidic body fluids of cancer survival, and nothing else. If your body is acidic, you will get cancer. If it is weak base, you will not get cancer. If you already have cancer, as long as you can adjust your body's PH value to weak alkaline, cancer will go away.
Peritoneal mesothelioma
Peritoneal mesotheliomaAtlas
The secret is very simple to prevent cancer is to eat alkaline foods to prevent the accumulation of acidic wastes, because the acidification of the fluid environment is fertile ground for normal cell cancerous, fluid acid-base balance adjustment is an effective way to prevent cancer.
A) to develop good habits, quit alcohol limit. Smoking , the World Weisheng Zu Zhi predicts that if people are not smoking, five years later, the world's cancer will be reduced by one-third; secondly, no alcohol. Tobacco and alcohol is very acidic acid, long-term smokers who drink alcohol, easily lead to acidic.
B) Do not eat too much salty and spicy food, eat hot, cold, overdue and bad food; frail or have some kind of disease genes are appropriate to eat some anti-cancer foods and high alkali content alkaline foods to maintain good mental state.
C) have a good mentality to cope with stress, rest, do not fatigue. Visible pressure is an important incentive for cancer, Chinese medicine, stress leads to fatigue physically weak to cause decreased immune function, endocrine disorders, in vivo metabolic disorders, leading to acid deposition in vivo; pressure can lead to mental stress caused by stagnation of qi and blood stasis, drugs, fire retraction and so on.
D) to enhance physical activity, enhance physical fitness, exercise in the sun, and more acidic the body sweat can be excreted with the sweat, to avoid the formation of acidic.
E) life to the law, irregular habits of people, such as the night singing karaoke the OK , playing mahjong , night out and other living without the law, will increase the acidic, prone to cancer. It should develop good habits, so as to maintain a weak alkaline, so far from their various types of cancer diseases.
F) not to eat contaminated food, such as contaminated water, crops , poultry, fish balls, moldy food, eat some organic food, to prevent the disease from the mouth.